The Impact of Bortezomib in Renal Transplantation

Kidney transplantation is one of the most common solid organ transplants that improves quality of life and promotes longevity of the patients. However, the access to transplantation is limited by the shortage of deceased donor organs and the presence of HLA antibodies prior transplantation. Many efforts have been made to promote living kidney donation due to the better survival rates, and desensitization protocols have been developed in order to abrogate or reduce the titers of anti-HLA antibodies. Several regimens can be used, including pretransplantation induction therapy and post-operative immunosuppression to prevent graft rejection, reduce morbidity and complications.